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Home > Products >  Buy High quality/lowest price of Dofetilide

Buy High quality/lowest price of Dofetilide CAS NO.115256-11-6

  • FOB Price: USD: 1.00-5.00 /Gram Get Latest Price
  • Min.Order: 1 Gram
  • Payment Terms: L/C,D/A,D/P,T/T
  • Available Specifications:

    98%(1-100)Gram98%(200-500)Gram

  • Product Details

Keywords

  • Buy Dofetilide
  • High quality of Dofetilide
  • lowest price of Dofetilide

Quick Details

  • ProName: Buy High quality/lowest price of Dofet...
  • CasNo: 115256-11-6
  • Molecular Formula: C19H27N3O5S2
  • Appearance: white crystal powder
  • Application: The circulatory system of drug ;Anti-a...
  • DeliveryTime: in stock
  • PackAge: Aluminum foil bag inside ,cardboard dr...
  • Port: Beijing , Shanghai or Qingdao
  • ProductionCapacity: 4 Kilogram/Week
  • Purity: >98%
  • Storage: Room temperature storage
  • Transportation: Mfg. add: No.9 Hexie Road, Biopark, Ka...
  • LimitNum: 1 Gram
  • Heavy Metal: 0 ppm
  • Valid Period: 2 years

Superiority

The basic information

More than a little (115256-11-6) is one of the more specific the first Ⅲ anti-arrhythmic drugs, it is to extend the time of action potential and effective refractory period, but does not affect the heart conduction velocity. The mechanism of these effects is that it can inhibit the fast part of the hysteresis outward potassium current, thus blocking the outflow of potassium ions during the repolarization phase. Relevant research shows that the drug can treat and prevent atrial arrhythmia, such as atrial fibrillation, atrial flutter and paroxysmal supraventricular tachycardia, but also prevent the occurrence of ventricular tachycardia. It has been shown to reduce the incidence of complications in patients with heart failure. The most serious adverse reaction to Dofeirite is the induction of ventricular arrhythmias (especially tip torsive ventricular tachycardia).

Details

Advantage

The mechanism of action is to block the fast part of the potassium channel in the heart, and prolong the action potential duration (Ikr). In several important concentrations, polyphilite only blocks Ikr, and has no correlation with other potassium ion current repolarization (e.g., Iks,Ik1). In clinically relevant concentrations, a little more on the sodium channel (associated with drug Ⅰ class), adrenergic receptor alpha or adrenergic receptor beta.

[Purpose 1]

Selective potassium channels agonists for Ⅲ anti-arrhythmic drugs, used for atrial fibrillation and atrial flutter.

[Purpose 2]

For maintenance and conversion to normal sinus rhythm in patients with atrial fibrillation (AF) and atrial flutter (AFL).

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