7081-53-0 Supply lowest price of Doxapram HCl factory CAS NO.7081-53-0

FOB Price: USD: /Metric Ton Get Latest Price
Min.Order: 10 Gram
Payment Terms: L/C,D/A,D/P,T/T,Other
Available Specifications:
98%(1-2)Metric Ton00/Metric Ton1USD

Product Details

Keywords

Supply Doxapram HCl
lowest price of Doxapram HCl
Doxapram HCle factory

Quick Details

ProName: 7081-53-0 Supply lowest price of Doxap...
CasNo: 7081-53-0
Molecular Formula: C24H33ClN2O3
Appearance: White or off-white powder
Application: pharmaceutical intermediates
DeliveryTime: immediate
PackAge: 1KG; 10KG; 25KG
Port: Any port in China
ProductionCapacity: 200 Metric Ton/Month
Purity: 99% Min
Storage: Preserved closely at room tempreture
Transportation: by courier, air or sea
LimitNum: 10 Gram
Moisture Content: NMT1%
Impurity: NMT1%

Superiority

7081-53-0 Supply lowest price of Doxapram HCle factory

English synonym：

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinonehydrochloridehydr;Doxapramhydrochloridemonohyd;1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-2-pyrrolidinonehydratehydrochloride;Dopramhydrochloridehydrate;ChemicalbookDOPRAMHYDROCHLORIDEHYDRATE;STIMULEXHYDROCHLORIDEHYDRATE;RESPIRAMHYDROCHLORIDEHYDRATE;Respiramhydrochloridehydrate;Stimulexhydrochloridehydrate;1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinonmonohydrochloride

Matters needing attention

1. It can cause headache, weakness, dyspnea, arrhythmia, nausea, vomiting, diarrhea and urinary retention, chest pain, chest tightness, elevated blood pressure, and local thrombophlebitis; Rare delirium, cough, vertigo, photophobia, extreme heat, excessive sweat, etc. Excessive performance for convulsion, involuntary tremor and hyperreflexia, can be saved by static injection.

2. It is forbidden for patients with epilepsy, convulsions and severe lung diseases.

3. Intracranial hypertension, severe hypertension, Chemicalbook heart disease, pregnant women and children under 12 years old should be used with caution.

4. Only use this product 10 to 20 minutes after using general anesthetics such as fluorane and isoflurane.

5. The intravenous drip rate should not be too fast, so as not to cause hemolysis. Leakage of fluid from the blood vessels during injection can cause irritation.

6. Excessive dosage may result in enhanced tendon reflexes, muscle tremors and convulsions.

7. Dosapuron hydrochloride combined with sympathetic drugs or monoamine oxidase inhibitors is likely to cause adverse cardiovascular reactions, which should be used with caution.

Details

use

Doxapram hydrochloride is a kind of central nervous system stimulants, belong to the central nervous system drugs, small doses can stimulate the carotid body and aortic body chemoreceptor reflex sexual excitement medulla oblongata respiratory center and cardiovascular center, its breath excitation is to brake meters high, high-dose excitement of spinal cord and brain stem, but on the brain cortex seems to no effect.

In addition, it has a mildly exciting effect on the cardiovascular system, which can cause a slight acceleration of pulse, increase cardiac output, and slightly increase blood pressure. The safe range of doxapron hydrochloride is large (i.e. the range between excitation and convulsive dose is large), and it is advisable to substitute tetrandrine, nikexamide, pentaerythritol, etc.

It is used for respiratory depression caused by central suppressive drugs, acute respiratory failure caused by other causes, COPD complicated with acute respiratory failure, and accelerated recovery after anesthesia operation.

Respiratory failure is a multiple cause of pulmonary ventilation and/or ventilation dysfunction that fails to maintain sufficient gas exchange in the resting state and leads to hypoxia with or without carbon dioxide retention, leading to a range of clinical syndromes with physiological and metabolic disorders.

Intravenous infusion and intravenous drip in adults: central inhibition wake-up, 1 ~ 2mg/kg each time, repeated once every 5min if necessary, maintained at a volume of 1 ~ 2mg/kg every 1 ~ 2 hours, until the effect was obtained, and the total amount per day was less than 3g.

It is used for waking up after anaesthesia, 0.5 ~ 1mg/kg each time, and can only be repeated once after at least 5min if necessary. The total amount is less than 2mg/kg, and the total amount is less than 4mg/kg in the case of static drops.

Intravenous injection can be diluted to less than 2mg/ml by sodium chloride injection or glucose injection. Static drops can be diluted with 5% glucose injection to a concentration of 1mg/ml, and the initial rate of administration is 5mg/min, until the therapeutic effect occurs, and the rate of administration is maintained at 1 ~ 3mg/min.